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The working principle of polyethylene glycol linking agent


Polyethylene is a kind of polymer with large molecular weight, which is widely used in biological research. Its working principle is mainly to use the hydrophilic and lipophilic properties of polyethylene glycol molecules to connect biomolecules together.
In biological experiments, researchers often need to link two biomolecules or compounds together to achieve certain experimental purposes. For example, linking drug molecules to carrier proteins can improve drug efficacy and reduce toxic side effects. As a neutral molecule, polyethylene glycol will not affect the structure and function of bioactive molecules. At the same time, due to its hydrophilic and lipophilic nature, it can improve the efficiency and stability of the connection.
The working principle of the polyethylene glycol linker can be further explained by the fact that in solution, the polyethylene glycol molecule will attract water molecules to form hydrogen bonds with it, while the lipophilic part of the polyethylene glycol chain will interact with other lipophilic molecules, thus linking the two biomolecules together. This connection can not only maintain the structure and function of biomolecules, but also increase their stability and solubility, making the experimental operation more convenient and effective.
In general, polyethylene glycol linker through its unique molecular properties, to achieve the connection between biological molecules, and play an important role in biological experiments.